Caffeine vs Amphetamines

A recent study shows that stimulants, such as caffeine and amphetamines, can affect different people in different ways, especially regarding work ethic. There are two kinds of people: self-motivated hard workers and those who do just enough to get by. Hard workers focus on the reward that awaits at the end of a task while others focus only on the effort required to accomplish something.

However, the research, which was conducted on rats, reveals a twist: stimulants like caffeine seem to flip those approaches. "The workers are choosing fewer of the hard trials, and the slackers are choosing more of the hard trials," said study researcher Jay Hosking, a graduate student at the University of British Columbia.

Hosking and his colleagues trained and tested how motivated 20  different rats were. They were put in boxes with two levers and five holes. During the task, one of the holes lit up. By sticking its nose in that hole, the rat received a treat of sugar pellets. Using the levers, the rats could then choose between a hard task, in which the hole lit up for a fifth of a second — about how long it takes to blink — and an easier one, where the hole lit for a whole second.

"Even the rats have extreme slackers and extreme workers," Hosking told LiveScience. "Just like with human beings, there is a continuum of activity levels." As in humans, some rats frequently chose the bare-minimum task, and others went with the hard ones for the bigger payoff.

When the rats were given stimulants like caffeine or amphetamines, they were more impulsive and responded quicker, but they were just as accurate at nosing the lit-up hole. However, the two personalities of rat had opposite reactions when made to choose between tasks. On either of the drugs, the hardworking rats became lazy, preferring the easy tasks in trials.

Meanwhile, when the lazy rats were given amphetamines, they became hard workers. Oddly, the same effect was not seen for the caffeine.

"The good news is that caffeine doesn't make the lazy rats any worse, but it definitely decreases the workers' willingness to put in the work," Hosking said.

Why the difference between the two stimulants? "Both end up stimulating, both create arousal, but they have different specific effects on the brain," he said.

The results may explain why amphetamine-based stimulants such as Adderall can help calm someone who has attention deficit hyperactivity disorder (ADHD). Perhaps the drug works to turn those distracted people into focused workers.

Adderall has lots of "off-label" uses, too, Hosking noted. Everyone from overworked college students to long-haul truck drivers may take amphetamines.

"One treatment doesn't fit all individuals," Hosking said.

"In truck drivers, amphetamine is a common stimulant which helps keep drivers alert … but a quarter of truck accidents are related to that amphetamine use as well," he said. "Some people might do really well on the amphetamines, and some might be taking it and thinking it's helping and actually harming themselves."